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KMID : 0869619980150020220
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Journal of Korean Society of Hospital Pharmacists
1998 Volume.15 No. 2 p.220 ~ p.223
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The Compatibility of Aminoglycosides with 10% Intralipose^(®) by Y-site Injection
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백진희/Baek, Jin Hee
박옥선/양유리/김재연/노환성/Park, Ok Sun/Yang, You Ri/Kim, Jae Yun/Ro, Hwan Seong
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Abstract
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For determine the stability of aminoglycosides with fat emulsion in Y-site, six aminoglycosides (amikacin, netilmicin, micronomicin, gentamicin, dibekacin and tobramycin) were added to 10% fat emulsion. All admixture were prepared and stored at room temperature under normal room lighting in plastic syringe. One volume of each drug in normal saline was added to an equal volume of 10% Intralipid. These admixtures were pH tested and visually inspected at instant, 10min, 30min, 1hr after. Emulsion particle size determined at instant, 10min, 30min, 1hr after using laser particle analyser. Although they did not result in visual breaking of all emulsions within 1hr, all drugs were incompatible with 10% Intralipid. We observed an increase in the size of the particles (1.5∼2 fold) and pH did not vary by more than 0.13 pH, but there were no admixture within permitable pH for the begin. Mean particle diameters remained relatively constant for ≤4㎛ in all the admixtures throughout the study period. Particles larger than 1 microns were observed. Therefore, in light of these results, aminoglycosides can not be administered via Y-site method with the 10% Intralipid.
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